You can solo using a frigate, but it requires 3x filament and has more loot than doing 1x filament with a cruiser.
Gates will not open until all enemies are dead.
Extraction nodes are optional. Sometimes they have no loot.
Biocombinative Cache always has loot and is the most important container.
A Mobile Tractor Unit (MTU) can be used to pull the extraction node loot for you.
If you go out of bounds you will die. An orange barrier appears if you get close.
Use “C” shortcut to Track objects and look at them to find them easier.
Tips for doing runs
Immediately check for towers and decide if you need to avoid to utilize any
Immediately check for clouds and identify any you should avoid
Immediately check the location of the extraction nodes. Decide if you want to skip them or get them and plan the best route. Sometimes you can go straight for the node, and kill enemies on your way if they come to you. In some cases, the enemies will kite you and you may need to chase them down first and then judge how much time you have left in the room.
Destroy the Extraction Nodes from a distance because sometimes they're empty and you can skip them.
Watch out for physical barriers and if be aware if containers are on the far side of an object.
Towers
Deviant Automata Suppressor - kills friendly and enemy drones